In this whitepaper, Broughton discusses the susceptibility of cannabinoids
to degrade and summarizes the main degradation pathways of the primary
cannabinoid products on the market; tetrahydrocannabinol (THC) and Cannabidiol
(CBD). The degradation pathways of these products are reviewed with consideration
of the potential impact on product effi cacy, consumer safety, and regulatory and
legal compliance. A high-level review of how these degradation pathways may
impact different dosage forms is provided, along with a consideration of how the
formation of these breakdown products may be mitigated.
This whitepaper forms a high-level synopsis of cannabinoid degradation, an
important consideration for manufacturers working with these products to comply
with key regulations or with the intention of submitting regulatory dossiers.